Influence of topically applied adrenergic agents on cochlear blood flow.
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چکیده
منابع مشابه
Influence of topically applied adrenergic agents on cochlear blood flow.
This study was designed to assess the role of adrenergic receptors in the control of cochlear blood flow. Laser Doppler flowmetry was used to determine the effects of adrenergic drugs topically applied to the round window membrane of the cochlea. The relative influence of the various receptor types (alpha 1, alpha 2, beta 1, and beta 2) was examined by a selection of agonists and antagonists. T...
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It has been hypothesized that acute lesions of the brain enlarge through an autodestructive process. Serotonin (5HT), a potent cerebral vasoconstrictor, is believed by some to mediate the process by reducing cerebral blood flow (CBF) in tissue surrounding the lesion. The hypothesis was tested in cynomologus monkeys anesthetized with ketamine and nitrous oxide. Craniectomies, 7 mm in diameter, w...
متن کاملThe effect of topically applied antimycotic agents on inner ear vestibular and cochlear function.
OBJECTIVES/HYPOTHESIS To assess and compare the effect of commonly used topical antimycotic agents and their solvents on the function of the vestibular and cochlear parts of the sand rat's inner ear. STUDY DESIGN Prospective, controlled, animal study. METHODS Forty-five fat sand rats were randomly assigned to five major groups, each receiving topical application of a different agent: saline...
متن کاملEffects of vasodilating agents on cochlear blood flow in mice.
The mouse has several distinct advantages as an experimental model for study of the cochlear blood flow (CBF) in the mammal, particularly for studies involving genetic manipulation, development and aging factors. In this investigation we evaluated the effects of selected vasodilating agents on CBF using laser-Doppler flowmetry. Sodium nitroprusside, hydralazine and pentoxifylline were applied t...
متن کاملCochlear blood flow in response to dilating agents.
Reduced cochlear blood flow (CBF) has been implicated in various pathologies of the inner ear, including sudden deafness, noise-induced hearing loss and Meniere's disease. Thus the aim of some current therapeutic regimens to treat these conditions is to increase CBF and thereby improve oxygenation of the inner ear tissues. Most of the vasodilating agents in clinical use, however, do not have sp...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1991
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.69.2.509